SignalDependentRegulationofMyogenesisbyCorepressorMITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds to promoters to activate genes involved in muscle cell differentiation. One of the factors that regulates the role of MyoD/MEF2 in myogenesis is the protein MEF2-interacting transcription repressor (MITR), a transcriptional repressor. When MITR is bound to MEF2, myogenes......閱讀全文
Signal－Dependent－Regulation－of－Myogenesis－by－Corepressor－MITR
The differentiation of muscle cells is regulated by many factors, including the MyoD/MEF2 family of transcription factors. The MyoD/MEF2 dimer binds t
Control－of－skeletal－myogenesis－by－HDAC－calcium/calmodulindependent－kinase
The differentiation of muscle cells is transcriptionally regulated, in part by the myocyte enhancer factor-2, MEF2. During myogenesis MEF2 binds to My
HDAC9基因編碼功能及結構描述
組蛋白在轉錄調控、細胞周期進展和發育事件中起著關鍵作用。組蛋白乙酰化/去乙酰化改變染色體結構并影響轉錄因子對dna的獲取。該基因編碼的蛋白質與組蛋白脫乙酰酶家族成員具有序列同源性。該基因與非洲爪蟾和小鼠二尖瓣基因同源。mitr蛋白缺乏組蛋白脫乙酰酶催化結構域。它通過招募包括ctbp和hdac的多組分
HDAC9基因突變與藥物因子介紹
組蛋白在轉錄調控、細胞周期進展和發育事件中起著關鍵作用。組蛋白乙酰化/去乙酰化改變染色體結構并影響轉錄因子對dna的獲取。該基因編碼的蛋白質與組蛋白脫乙酰酶家族成員具有序列同源性。該基因與非洲爪蟾和小鼠二尖瓣基因同源。mitr蛋白缺乏組蛋白脫乙酰酶催化結構域。它通過招募包括ctbp和hdac的多組分
HDAC9基因編碼功能及結構描述
組蛋白在轉錄調控、細胞周期進展和發育事件中起著關鍵作用。組蛋白乙酰化/去乙酰化改變染色體結構并影響轉錄因子對dna的獲取。該基因編碼的蛋白質與組蛋白脫乙酰酶家族成員具有序列同源性。該基因與非洲爪蟾和小鼠二尖瓣基因同源。mitr蛋白缺乏組蛋白脫乙酰酶催化結構域。它通過招募包括ctbp和hdac的多組分
Hypoxia－and－p53－in－the－Cardiovascular－system
Hypoxic stress, like DNA damage, induces p53 protein accumulation and p53-dependent apoptosis in oncogenically transformed cells. Unlike DNA damage, h
Map－Kinase－Inactivation－of－SMRT－Corepressor
Corepressors are coregulators that interact with transcriptional silencers in a variety of pathways such as cell proliferation, differentiation and ap
Visual－Signal－Transduction
The signal transduction cascade responsible for sensing light in vertebrates is one of the best studied signal transduction processes, and is initiate
BCR－Signaling－Pathway
Significant progress has been made towards delineation of the intrinsic molecular processes that regulate B lymphocyte immune function. Recent observa
Ahr－Signal－Transduction－Pathway
The Ah receptor, bHLH/PAS transcription factor, upon binding of an agonist such as 2,3,7,8-tetrachlorodibenzo-p-dioxin translocates into the nucleus a
Keratinocyte－Differentiation
The epidermis, which provides a protective barrier that undergoes a constant renewal, is a multi-layered tissue with the proliferating cells located i
Regulation－of－BAD－phosphorylation
The function of the pro-apoptotic molecule BAD is regulated by phosphorylation of three sites (ser 112,136 and 155). Phosphorylation at these sites re
Regulation－of－Spermatogenesis－by－CREM
The transcriptional regulator CREM plays a key role in spermatogenesis, acting as a central transcription factor triggering a cascade of transcription
Regulation－of－hematopoiesis－by－cytokines
The process of hematopoesis is regulated by various cytokines. The combination of cytokines stimulates the proliferation and/or differentiation of the
Skeletal－muscle－hypertrophy－is－regulated－via－AKT/mTOR－pathway
Skeletal muscle atrophies with disuse while with increased use and increased load skeletal muscle exhibits hypertrophy, with an increase in the size o
Antigen－Dependent－B－Cell－Activation
A key part of the immune system is the production of immunoglobulins (antibodies) by B cells to bind and inactivate specific foreign antigens. The bod
IL7－Signal－Transduction
IL-7 is a key cytokine in the immune system, essential for normal development of B cells and T cells. Mice with the IL-7 receptor deleted lack B and T
Regulation－And－Function－Of－ChREBP－in－Liver
Liver is the major site for carbohydrate metabolism (glycolysis and glycogen synthesis) and triglyceride synthesis (lipogenesis). While insulin was lo
Cyclins－and－Cell－Cycle－Regulation
The cell cycle is regulated by the interplay of many molecules. Key among these are the cyclins which are expressed and then degraded in a concerted f
CDK－Regulation－of－DNA－Replication
Initiation of DNA replication in eukaryotes is a highly conserved, multi-step process (replication licensing) designed to restrict initiation events t
ChREBP－regulation－by－carbohydrates－and－cAMP
Although insulin and glucagon play important roles in regulating the response of cells to nutrients, cells also respond to carbohydrates through trans
Stress－Induction－of－HSP－Regulation
Mammalian cells can respond to a variety of stresses such as heat, cold, oxidative stress, metabolic disturbance, and environmental toxins through nec
Regulation－of－transcriptional－activity－by－PML
The PML nuclear bodies are ring-shaped nuclear substructures associated with the regulation of transcription, transformation, cell growth, and apoptos
Regulation－of－PGC1a
Peroxisome proliferator-activated receptor gamma coactivator-1 alpha (PGC-1a) is a tissue-specific coactivator that enhances the activity of many nucl
Regulation－of－eIF2
Protein phosphorylation plays an important role in the control of translation by eukaryotic initiation factor-2 (eIF-2). eIF-2 binds GTP and Met-tRNAi
PTEN－dependent－cell－cycle－arrest－and－apoptosis
PTEN is a tumor suppressor gene. Recombinant PTEN is capable of dephosphorylating phosphatidylinositol 3,4,5-triphosphate[PI(3,4,5)P3], the product of
SUMOylation－as－a－mechanism－to－modulate－CtBPdependent－gene－responses
Covalent attachment of one eukaryotic protein to another is a prominent posttranslational modification and Ubiquitin is the most familiar of the prote
Eukaryotic－protein－translation
The scanning translation initiation model suggests that 40S ribosomal subunit preloaded with factors bind to the 5’ end of the mRNA near the cap. The
Role－of－Ran－in－mitotic－spindle－regulation
One of the central features of mitotic cell division is the formation of the spindle that segregates chromosomes into each daughter cell. Chromosomes
FXR－and－LXR－Regulation－of－Cholesterol－Metabolism
Cholesterol is essential for life and a key in the development of heart disease. Cholesterol homeostasis is achieved through regulation of cholesterol