該基因編碼一種蛋白質，在dna雙鏈斷裂修復途徑選擇、促進非同源末端連接（nhej）途徑和限制同源重組中發揮作用。該蛋白在dna損傷反應中發揮多種作用，包括促進dna損傷后的檢查點信號傳導，作為dna損傷反應蛋白向受損染色質募集的支架，以及通過限制雙鏈斷裂后的末端切除促進nhej途徑。這些作用在v（d）j重組、類開關重組和未保護端粒中也很重要。選擇性剪接導致編碼不同亞型的多個轉錄變體。[由RefSeq提供，2017年8月]
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]