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    發布時間:2022-08-22 15:01 原文鏈接: SHBG基因編碼的功能和結構描述

    該基因編碼一種類固醇結合蛋白,最初被描述為肝臟分泌的血漿蛋白,但現在被認為參與類固醇反應的調節。編碼的蛋白質在血液中運輸雄激素和雌激素,將每個類固醇分子結合成由相同或幾乎相同的單體形成的二聚體該基因多態性與多囊卵巢綜合征和2型糖尿病有關。選擇性剪接導致多個轉錄變體。

    This gene encodes a steroid binding protein that was first described as a plasma protein secreted by the liver but is now thought to participate in the regulation of steroid responses. The encoded protein transports androgens and estrogens in the blood, binding each steroid molecule as a dimer formed from identical or nearly identical monomers. Polymorphisms in this gene have been associated with polycystic ovary syndrome and type 2 diabetes mellitus. Alternative splicing results in multiple transcript variants.

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