鈣蛋白酶是一個普遍存在的、保存良好的鈣依賴性半胱氨酸蛋白酶家族calpain蛋白是由不變的小亞基和可變的大亞基組成的異二聚體大亞單位具有半胱氨酸蛋白酶結構域，并且兩個亞單位都具有鈣結合結構域鈣蛋白酶被牽連在神經退行性過程中，因為它們的激活可以由鈣內流和氧化應激觸發。這個基因編碼的蛋白質的功能尚不清楚。在老鼠身上發現了一個正射影像，但它似乎與其他家庭成員不同。小鼠原腸被認為是鈣獨立的蛋白酶活性。[由RefSeq提供，2008年7月]
Calpains are ubiquitous, well-conserved family of calcium-dependent, cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. The large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes, as their activation can be triggered by calcium influx and oxidative stress. The function of the protein encoded by this gene is not known. An orthologue has been found in mouse but it seems to diverge from other family members. The mouse orthologue is thought to be calcium independent with protease activity. [provided by RefSeq, Jul 2008]