該基因被鑒定為一種能被腫瘤壞死因子（TNF）快速誘導表達的基因。該基因編碼的蛋白是鋅指蛋白和ubiqitin編輯酶，具有抑制nf-kappa b激活和腫瘤壞死因子介導的細胞凋亡的作用。編碼的蛋白具有泛素連接酶和氘蛋白酶活性，參與細胞因子介導的免疫和炎癥反應。已經發現了一些編碼相同蛋白質的轉錄變體。[由RefSeq提供，2012年7月]
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]