該基因編碼的蛋白與Ⅱ類主要組織相容性復合體（mhc）相關，是調節免疫應答抗原提呈的重要伴侶。它還充當細胞因子-巨噬細胞移動抑制因子（mif）的細胞表面受體，mif與編碼蛋白結合后，啟動生存途徑和細胞增殖。該蛋白還與淀粉樣前體蛋白（app）相互作用，抑制淀粉樣β（abeta）的產生。已經鑒定出編碼不同亞型的多個選擇性剪接轉錄變體。[由RefSeq提供，2011年8月]
The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]